[Kido]

What can go wrong by always using the e-shift if anything?

 

[Risk3233]

Nothing mechanically to the car.

Maybe sore fingers.

 

[TEG]

Your fingers get tired

Actually if you for it to rev to redline every time your transmission and engine will have more wear than normal... But it is a Toyota/Lexus so should last a long time anyways.

If you drive the car really hard make sure to change the engine oil and transmission oil a bit more often than recommended.

 

[REVscene.net]

Disadvantages:

-Wear and tear of engine
-Wear and tear of the buttons; mine are starting to not depress smoothly as before..

 

[old dude]

You will get worse gas mileage also.
I am disappointed the the other post that says that the shift is not so smoothe any more.
I sure hope Lexus didn't faill us in quality on this bird. It is a first year car and maybe we all jumped too soon.